First, this should have been posted in the Audio and Electronics thread. Then all of the audiophiles on this board would have chimed in a little earlier.
Second, you need to be more specific on what you want. Like someone mentioned before are you looking for a lot of bass so that you can be heard from blocks away? Or are you looking for something that can sooth your stress (extremely SQ oriented)?
Third, we need to know what your budget is and how much work you are willing to put into this system.
Also you need to remember that you are asking people for there opinions, so it may not be the best solution for you but it should help put you in the right direction. Not to mention some of us here have stereo's that are almost worth more than are TVs at the present time.
So give us a little more info and we can help you decide on a system on a budget all the way to the extreme.